Multifunctional Fullerene- and Metallofullerene-based Nanobiomaterials
نویسنده
چکیده
Recent advances in nanotechnology have enabled the synthesis and characterization of nanomaterials suitable for applications in the ̄eld of biology and medicine. Due to their unique physicochemical properties, carbon-based nanomaterials such as fullerenes, metallofullerenes, carbon nanotubes and graphene have been widely investigated as multifunctional materials for applications in tissue engineering, molecular imaging, therapeutics, drug delivery and biosensing. In this review, we focus on the multifunctional capabilities of fullerenes and metallofullerenes for diagnosis and therapy. Speci ̄cally, we review recent advances toward the development of fullereneand metallofullerene-based magnetic resonance imaging (MRI) and X-ray imaging contrast agents, drug and gene delivery vehicles, and photodynamic therapy agents. We also discuss in vitro and in vivo toxicity, and biocompatibility issues associated with the use of fullerenes and metallofullerenes for biomedical applications.
منابع مشابه
Synthesis and UHV-STM observation of the T(d)-symmetric Lu metallofullerene: Lu2@C76(T(d)).
The first T(d)-symmetric lutetium metallofullerene, Lu(2)@C(76), has been synthesized, isolated, and characterized. Because of the charge transfer from the encapsulated Lu atoms to the T(d)-C(76) fullerene cage, the otherwise unstable T(d)-C(76) fullerene can be significantly stabilized as a Lu(2)@C(76) fullerene. Both STM and STS results are consistent with a charge state of (Lu(2))(6+)@C(76)(...
متن کاملPartial charge transfer in the shortest possible metallofullerene peapod, La@C82 ⊂[11]cycloparaphenylene.
[11]Cycloparaphenylene ([11]CPP) selectively encapsulates La@C82 to form the shortest possible metallofullerene-carbon nanotube (CNT) peapod, La@C82 ⊂[11]CPP, in solution and in the solid state. Complexation in solution was affected by the polarity of the solvent and was 16 times stronger in the polar solvent nitrobenzene than in the nonpolar solvent 1,2-dichlorobenzene. Electrochemical analysi...
متن کاملDesigns of fullerene-based frameworks for hydrogen storage
Designs of fullerene-based frameworks for hydrogen storage" (2014). Holland Computing Center-Faculty Publications. Paper 2.Designs of fullerene-based frameworks for hydrogen storage" (2014). Xiao Cheng Zeng Publications. Paper 112. Two types of hybrid metallofullerene framework are theoretically designed, and their structural stabilities are examined using the density functional theory (DFT) co...
متن کاملIn vivo studies of fullerene-based materials using endohedral metallofullerene radiotracers.
Biodistribution studies of a water-soluble radioactive metallofullerene compound have been conducted using BALB/c mice. To this end, a sample containing Hox@C82 (x = 1, 2) was purified and derivatized to prepare the water-soluble metallofullerol, Hox@C82(OH)y. This metallofullerol was then neutron-activated (165Ho[n,gamma]166Ho) to prepare the 166Hox@C82(OH)y analog as a radiotracer, which was ...
متن کاملElectrochemical and magnetic properties of a surface-grafted novel endohedral metallofullerene derivative.
A novel endohedral metallofullerene (EMF) has been designed and synthesised for its grafting on gold. The functionalization of the substrate resulted in a multifunctional surface displaying the properties of the EMF in solution.
متن کامل